5th Users' Conference of IT4Innovations

Session

Users` Talk I

9 Nov 2021, 13:00

Online (IT4Innovations)

74. Weakly Hydrated Anions Bind to Polymers but Not Monomers in Aqueous Solutions

Jan Heyda (University of Chemistry and Technology, Prague)

09/11/2021, 13:00

Users' talks

User's talk

Weakly hydrated anions help to solubilize hydrophobic macromolecules in aqueous solutions, but small molecules comprised of the same chemical constituents precipitate out when exposed to these ions. Herein, this apparent contradiction is resolved by systematically investigating the interactions of NaSCN with polyethylene oxide oligomers and polymers of varying molecular weight. A combination...

89. Molecular dynamics simulations of electron-transfer through tryptophan chains and a rhenium chromophore in modified azurins

Dr Stanislav Záliš (J. Heyrovský Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, Dolejškova 3, CZ-182 23 Prague, Czech Republic)

09/11/2021, 13:20

Users' talks

User's talk

Dynamical factors controlling hopping speed and efficiency in two modified azurin constructs that include a rhenium(I) sensitizer, Re(His)(CO)3(dmp)+, one or two tryptophans (W1, W2) and CuI center were studied by femtosecond time-resolved spectroscopy. Experimental kinetics investigations showed that the two closely spaced (3-4 Å) intervening tryptophans dramatically accelerated long-range...

79. Peptide deformylase as a probe of long-range allostery between ribosome surface and interior

Michal H. Kolar (University of Chemistry and Technology)

09/11/2021, 13:40

Users' talks

User's talk

Ribosomes are complex biomachines responsible for protein synthesis in all organisms. The ribosome consists of three strands of RNA and dozens of ribosomal proteins. It is organized into two subunits, where the small subunit reads the mRNA and the large subunit catalyzes peptide bond formation. The nascent protein translocates from the catalytic center to the ribosome surface through a 10...