Our study represents the most comprehensive next-generation sequencing analysis of extramedullary multiple myeloma (EMM) tumor cells to date, uncovering key molecular features and describing the tumor microenvironment. We found the co-occurrence of 1q21 gain/amplification and MAPK pathway mutations in 79% of EMM samples, suggesting these are crucial mutational events in EMM development....
Accurate estimation of protein–ligand binding affinity is the cornerstone of computer-aided drug design. We have developed a universal physics-based scoring function, named SQM2.20, addressing key terms of binding free energy using semi-empirical quantum-mechanical computational methods. SQM2.20 incorporates the latest methodological advances while remaining computationally efficient even for...
Ribosome is particularly famous as a key player in protein synthesis. This large biomolecular complex of ribosomal RNA and ribosomal proteins catalyses peptide bond formation in all known cells. Within a so-called accretion model it is believed that during evolution, ribosome grew in size and chemical complexity. Hence, the central parts of the ribosome are molecular fossils that suggest how...
